Reading is not only “cold” information processing, but involves affective and aesthetic processes that go far beyond what current models of word recognition, sentence processing, or text comprehension can explain. To investigate such “hot” reading processes, standardized instruments that quantify both psycholinguistic and emotional variables at the sublexical, lexical, inter-, and supralexical levels (e.g., phonological iconicity, word valence, arousal-span, or passage suspense) are necessary. One such instrument, the Berlin Affective Word List (BAWL) has been used in over 50 published studies (...) demonstrating effects of lexical emotional variables on all relevant processing levels (experiential, behavioral, neuronal). In this paper, we first present new data from several BAWL studies. Together, these studies examine various views on affective effects in reading arising from dimensional (e.g., valence ) and discrete emotion features (e.g., happiness ), or embodied cognition features like smelling. Second, we extend our investigation of the complex issue of affective word processing to words characterized by a mixture of affects. These words entail positive and negative valence, and/or features making them beautiful or ugly. Finally, we discuss tentative neurocognitive models of affective word processing in the light of the present results, raising new issues for future studies. (shrink)

Rhodopsin, upon activation by light, transduces the photon signal by activation of the G‐protein, transducin. The well‐studied rhodopsin/transducin system serves as a model for the understanding of signal transduction by the large class of G‐protein‐coupled receptors. The interactive form of rhodopsin, R*, is conformationally similar or identical to rhodopsin's photolysis intermediate Metarhodopsin II (MII). Formation of MII requires deprotonation of rhodopsin's protonated Schiff base which appears to facilitate some opening of the rhodopsin structure. This allows a change in conformation at (...) rhodopsin's cytoplasmic surface that provides binding sites for transducin. Rhodopsin's 2nd, 3rd and putative 4th cytoplasmic loops bind transducin at sites including transducin's 5 kDa carboxyl‐terminal region. Site‐specific mutagenesis of rhodopsin is being used to distinguish sites on rhodopsin's surface that are important in binding transducin from those that function in activating transducin. These observations are consistent with and extend studies on the action of other G‐protein‐coupled receptors and their interactions with their respective G proteins. (shrink)

: This article is concerned with Newton's appropriation of Descartes' ontology of true and immutable natures in developing his theory of infinitely extended space. It contends that unless the part played by the Platonic distinction between "being a nature" and "having a nature" in Newton's thinking is properly appreciated the foundation of his doctrine of space in relation to God will not be fully understood. It also contends that Newton's Platonism is consistent with his empiricism once the mediating role is (...) made clear that the geometry of moving loci play in grounding his intuitions concerning infinite natures. (shrink)

Restrictions on research on therapeutic cloning are questionable as they inhibit the development of a technique which holds promise for succesful application of pluripotent stem cells in clinical treatment of severe diseases. It is argued in this article that the ethical concerns are less problematic using therapeutic cloning compared with using fertilised eggs as the source for stem cells. The moral status of an enucleated egg cell transplanted with a somatic cell nucleus is found to be more clearly not equivalent (...) to that of a human being. Based on ethical considerations alone, research into therapeutic cloning should be encouraged in order to develop therapeutic applications of stem cells. (shrink)

Descriptions of battles in ancient authors are not mirrors of reality, however dim and badly cracked, but are a form of literary production in which the real events depicted are filtered through the literary, intellectual, and cultural assumptions of the author. By comparing the battle descriptions of Julius Caesar to those of Xenophon and Polybius this paper attempts to place those battle descriptions in their intellectual and cultural context. Here Caesar appears as a military intellectual engaged in controversies with experts (...) in the Greek tradition of military theory-rejecting materialist strains of Greek thinking-and also as a Roman soldier whose military experience and cultural conceptions about how battles work could not be fully accommodated by Greek models. Caesar adapts from the Greeks an intellectual model of tactics based on physical metaphors, but adjusts Greek theory to Roman experience: Caesar's tactical physics ramifies from the crash-impetus-of the legionary charge rather than the push of the phalanx. Caesar also adapts from the Greeks a simplifying model of military psychology, adjusting a Greek binary scheme of morale into a three-level model to accommodate a Roman military ethos of steadiness in combat. Greek military thinking downplayed the role in battle of innate differences in courage between armies or nations, concentrating instead on tactics and stratagems; Roman culture encouraged Caesar to reject this dismissive view and elaborate a detailed understanding of the role of courage-virtus-in the mechanics of battle. The prominence of virtus in Caesar's battle descriptions illustrates its survival as an important Roman cultural norm and tempts speculation as to its historical consequences. Attempts to reconstruct ancient battles must take into account the cultural and intellectual traditions which guide ancient battle descriptions. (shrink)

In this book review I argue that, broadly speaking, there are three rival accounts of the relationship between having a normative reason to act and being motivated to act. Neo-Humeans argue that an agent has a normative reason to act if and only if so doing would satisfy some desire of the agent; consequently, their task is to show that there is an internal relation between an agent’s having a normative reason to act and an agent’s having a desire to (...) act. Kantians argue that any agent who has a normative reason to act, and who is practically rational (i.e., not suffering from some debilitating form of practical irrationality, such as weakness of will or depression), will act; consequently, their task is to show that normative reasons always have overriding authority and that it is always irrational not to act upon them. Neo-Aristotelians argue that normative reasons for action are derived from facts about human well-being, and that an agent will be motivated to act provided that she has been habituated into having desires, guided by reason, to act for her own well-being; consequently, their task is to show how normative reasons can be derived from facts about human well-being and whether it is always in an agent’s best interest to act morally. (shrink)